Everything about Coating process

Everything about Coating process

The tablets (from Latin tabuletta) are single-dose solid dosage forms which under pressure of powder or granules on tablet presses are manufactured. The forms of the tablets are different. Especially when taking oral tablets is the biconvex shape (round, up and down curved). A share of almost 50% of all forms of drug tablets makes a special position. In the pharmacopeoia (European Pharmacopoeia (PhEur)), the tablets called Compressio.
This name however was successful in pharmaceutical technology, nor on other medical areas.
Very many active ingredients can be embossed ë patients.
What direct, what most of the middle stage of the grains without any further processing of the powder or powder mixture (the direct tableting) means. In most cases, the extra aid materials required in addition to the actual active substance. The direct tableting is that the powder or the pre-treatment of powder mixtures more prints with or without the addition of AIDS without. It seems so easy and cheap. The downside is that only a few substances have the characteristics necessary to tableting, in particular the fluidity of the stacks and the band forces between the particles to lead. Coarse may be crystalline powder with cubic Crystal best be processed. A particle size of 0. 5 to 1 mm is ideal.
The powder would be dry, so has a residual moisture content of 10% and in printed spaces, which is a maximum relative humidity of 50%.
The addition of help will be necessary for the properties in the powder mixture Heufeld improve and changed the properties of all d ended tablet ë. Improve the flow properties of Haufwerkes: the stearate of Hochdisperses has a high specific surface and can customize up to 40% water, without losing its fluidity.
Another example: talk powderYou benefiting sustainable tablets (= improvement of particle adhesion) and the further disintegration of tablets in the gastro intestinal tract prints to improve: the cellulose, microcrystalline cellulose or cellulose mainly micro-fine, resulted in bruchfesten tablets, but aggravated the flow properties.
By their ability to source, powdered cellulose requires a short decay time.
More binders are the cellulose derivatives of HPMC and HPC, as well as Polyvinylpyrrolidone (PVP-Kollidone). These are very efficient ë nt nat Binder. The dry absorb (granulation without water) in turn includes the variants of HPC, as well as Copovidone. The Group of the explosive devices or decay-promoting resources is brands especially cross-begesturde automatically along certain PvP (Kollidon cl). The dragees consist of a core and a smooth, seamless layer. The core usually consists of a tablet or a grain and grain. The applied low or of sugar (= classic sugar Dragée) or of any other filmformers (film-coated tablets =). The layer is usually colored and can, where appropriate, or other substances, the properties of the finished dosage form ë ' I give on to change the way you want (odour, taste,. ) The process of coating is the packaging of a core with layers of sugar. Today, more and more other coating materials used. The layer is only é é n single thin film, which about film-coated tablets speaks. This is the classic coating process, I. the coating of cores with sugar solutions. The high production costs, the difficulties of the process (automate) to standardize and old of even é é n week per party could withdraw more and more this procedure in favour of the film-coated tablet. In the cold dragieren the sugar solution at normal room temperature is applied, the heated sugar syrup used in hot dragieren (called dragieren) (b. ca..
50-60 . The operation takes place in coating boilers, in which the nuclei by rotation of the drum are placed in the roles. The coating fluid is added gradually, and treats the nuclei. At the same time (hot air or IR channels) will be carefully dry. The process is repeated until has formed a sufficiently thick and stable layer around the core. This may require up to 50 coating operations. The cores experience these weight and volume increases. The difference is that the core Dragierung with a single, uninterrupted, colored special coating layer coated materials is. Neither the volume nor change the shape of the core this. Engraving remains visible. Although this layer is very thin, they'd all essential ë le advantages of properties must be retrieved in reasons for the coating are meant.

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